Mifepristone for uterine fibroids

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Different dosages of mifepristone versus enantone to treat uterine fibroids

BACKGROUND To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids. METHODS This is a Multicenter randomized controlled trial. A total of 501 subjects with symptomatic uterine fibroids were enrolled and randomized into the group of 10mg, 25mg mifepristone and 3.75 enantone (with 307, 102 and 92 subjects respective...

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Uterine fibroids.

Copyright © 2013 Massachusetts Medical Society Uterine fibroids (leiomyomas) represent the most common tumor in women. These lesions disrupt the functions of the uterus and cause excessive uterine bleeding, anemia, defective implantation of an embryo, recurrent pregnancy loss, preterm labor, obstruction of labor, pelvic discomfort, and urinary incontinence and may mimic or mask malignant tumors...

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A Pearl for Uterine Fibroids

Why was this study done? Few studies have explored the utility of medical interventions in the management of uterine fibriods. A 2011 report by the Agency of Healthcare Research and Quality [1] concluded that the literature examining the effectiveness of treatment strategies was scanty. Gonadotropinreleasing hormone (GnRH) analogues, such as leuprolide acetate, have shown promise in the suppres...

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Treatment For Symptomatic Uterine Fibroids

Symptomatic fibroids affect one in every three women over the age of 35, and are responsible for approximately 30% of all hysterectomies. The precise etiology of fibroids is unknown, but studies suggest that estrogen stimulation is an important factor. Fibroids tend to grow after puberty or during pregnancy, and usually decrease in volume in the post-menopausal period. Classification of Fibroid...

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Uterine fibroids: current perspectives

Uterine fibroids are a major cause of morbidity in women of a reproductive age (and sometimes even after menopause). There are several factors that are attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology. The most likely presentation of fibroids is by their effect on the woman's menstrual cycle or pelvic pr...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2012

ISSN: 1465-1858

DOI: 10.1002/14651858.cd007687.pub2